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Abstract
Background: Helicobacter pylori is a microorganism considered the main risk factor in the development of gastric cancer. In this paper we inform a detailed characterization of the probiotic properties and the anti -H. pylori activity of a previously isolated lactobacillus strain - Lactobacillus fermentum UCO-979C - obtained from human gut.
Results: The strain tolerated pH 3.0, grew in the presence of 2% bile salts, produced lactic acid and hydrogen peroxide, aggregated in saline solution, showed high hydrophobicity, was highly adherent to glass and to Caco-2 and Gastric adenocarcinoma human cells (AGS) cells, showed an efficient colonization in Mongolian Gerbils, and it potently inhibited growth and urease activity of H. pylori strains. L. fermentum UCO-979C significantly inhibited H. pylori-induced IL-8 production in AGS cells and reduced viability of H. pylori. Regarding its innocuousness, UCO-979C was susceptible to several antibiotics. The strain did not produce histamine or beta hemolysis in blood agar containing red blood cells from various origins.
Conclusion: The results presented demonstrate that L. fermentum UCO-979C is a very good candidate as a probiotic able to protect humans against H. pylori infections.Upon acceptance of an article by the journal, authors will be asked to transfer the copyright to Electronic Journal of Biotechnology, which is committed to maintain the electronic access to the journal and to administer a policy of fair control and ensure the widest possible dissemination of the information. The author can use the article for academic purposes, stating clearly the following: "Published in Electronic Journal of Biotechnology at DOI:10.2225/volXX-issueX-fulltext-XX".
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